MIKE REDDY FOR STAT
by Andrew Joseph
“The coronavirus behind the pandemic presents some vexing dualities.
“It’s dangerous enough that it dispatches patients to hospitals in droves and has killed more than 1.6 million people, but mild enough that most people shrug it off. It blocks one arm of the immune system from responding as it takes hold, but lures other parts into dangerous hyperdrive. It homes in on cells high up in the airway — think the nose and throat — but also burrows deeper into the lungs, maximizing infectiousness without ceding how sick it can make people.
“’It’s sort of right in that sweet spot,’ said Kristian Andersen, an infectious disease expert at Scripps Research Institute.
“A year into the pandemic, STAT is outlining a portrait of SARS-CoV-2 based on what scientists learned as the virus raced around the world, crippling some economies, societies, and health systems in its wake.
“How the virus cracks open cells and wards off the body’s first-line attack. How it can spread before people start feeling sick. How it’s changed since the dawn of the pandemic, and what, if anything, that means. How the omnivorousness of the disease it causes, called Covid-19, reaches not just the lungs but into the heart, brain, gut, and beyond.
“How this virus has caused the damage it has, unlike other respiratory viruses that also prey on our impulses to get together — to pack into crowds, to laugh, to sing — and use them as stepping stones in their mission to infect cells and make copies of themselves.”
